Biography
Prof. Xiumei Mo
Prof. Xiumei Mo
Donghua University, China
Title: Electrospinning 3D nanofiber scaffold for tissue engineering
Abstract: 
Electrospinning fabrication technique most commonly produces relatively 2D mats and the construction 3D structure nanofibers with higher porosity is still a major challenge. In this study, two methods were used to fabricate the 3D nanofiber scaffolds. A dynamic electrospinning method were developed to fabricate the nanoyarn scaffold, by this way electrospun poly(L-lactide-co-ε-caprolactone)/collagen (P(LLA-CL)/Col) nanofibers were deposited and twisted into yarns in a water vortex before collecting on a rotating mandrel to form a nanoyarn scaffold. The nanoyarn scaffold contained 3D aligned microstructures with larger interconnected pores and higher porosity comparing with nanofiber scaffold. The nanoyarn scaffold have been successfully used for tendon tissue regeneration of rabbit and blood vessel tissue regeneration in rat. Gelatin/PLA nanofiberous scaffold was fabricated by using combined electrospinning and freeze-drying. Gelatin/PLA nanofibers membranes were prepared by electrospinning; secondly, nanofibers membranes were cut into small pieces and were dispersed in tert-butanol by homogenizer; thirdly, the dispersions were frozen and freeze dried. Finally the scaffold was crosslinked by heating at 190OC or grafting HA on the nanofibers surface of scaffold by EDC/NHS. Thus obtained 3D nanofiber scaffold could promote cells growth and proliferation. In order to evaluate the repair capacity of 3D scaffold in vivo, an articular cartilage defect was created on rabbits and scaffolds were implanted into the defect. The in vivo study indicated that the cartilage repair capacity of scaffold without HA was limited, but scaffold modified with HA could enhance the repair of cartilage.
Biography: 
Prof. Dr. Xiumei MO is a professor of Biomaterials in Donghua University. She once had two years Postdoc experience in Kyoto University, three years research fellow experience in National University of Singapore, one year visiting professor experience in Aachen University of Applied Science and Technology. In Donghua University she was granted 28 projects related with nanofiber fabrication for different tissue regeneration and hydrogel as tissue adhesive. She has published more than 300 papers. ISI Web of Science showed that she ranking No.7 in the world on electrospun nanofiber publication. She got the Science Technical Invention Awards from Shanghai Municipality in 2008,Science and Technology Progress Awards from State Department of People’s Republic of China in 2009, Nature Science Awards from Shanghai Government in 2015. She is the committee members of China Biomaterials Society as well as Biomedical Engineering Society Biomaterials Branch. She is also vice chairman of China Composite Materials Society Super-fine Fiber Branch.