Raman spectroscopy is a powerful nondestructive analytical technique that possesses many advantages including high selectivity, quick response and its ability to provide rich information about the targets species without needing for sample preparation. Nevertheless, the weak Raman intensity has limited its applications for detecting trace species. Several techniques were applied for enhancing the Raman signals; among these techniques, surface-enhanced Raman scattering (SERS) is the most commonly used Raman enhancement technique [1] that enabling detection at very low concentration levels with high selectivity and sensitivity in presence of metal nanoparticles [2]. Several noble metals including silver (Ag), gold (Au) or copper (Cu) nanostructures with different size and shapes have been used as high active-SERS agents [3–7]. The chemical nature, size, shape, and spacing of the metal nanomaterials have the main influences on the intensity of the SERS signals. Ag nanostructured showed the highest SERS signals, but the low stability of Ag nanostructures hindering its SERS applications. Although there is notable progress in SERS research, many challenges achieving a repeatable and quantitative SERS signal and fabrication of uniform and stable nanoparticles hindering its development. Here, fabrication of metal/polymer as shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) for enhancing the intensity of the Raman signals and their applications will be discussed.