Doxorubicin (Dox) is a potent antineoplastic drug used to treat variety of tumors in cancer patients; however, this drug induces myocyte necrosis and apoptosis that leads to cardiotoxicity (DIC) and heart failure. This remains unknown whether Dox induced apoptosis or necrosis enhances infiltration of monocytes and causes increase in M1 macrophages differentiation that initiates inflammation and inflammation induced cardiac myocyte cell death pyroptosis in the heart that leads to adverse remodeling and heart dysfunction. We will present data on the presence of monocyte infiltration, macrophage differentiation and initiation of pyroptosis with TLR-4 and NLRP-3 pathway. Moreover, we will present that leads to downstream pyroptosis markers caspase-1, IL1-β, Caspase-11, and gasdermin-D. Moreover, this initiation and pyroptosis involves inflammatory cytokines such as TNF-α and IL-6. Next we will discuss how exosomes derived from embryonic stem cells influence inflammatory macrophages to differentiate into anti-inflammatory M2 macrophages and inhibit inflammation and pyroptosis in this drug induced cardiac heart failure. Furthermore, we will delineate what kind of components present in the ES-Exos that decreases inflammation and pyroptosis in DIC.

Dr. Dinender Singla received his B.Sc. and M.Sc. degrees from Punjabi University, Patiala, India and his Ph.D. from the Post Graduate Institute of Medical Education and Research, Chandigarh, India. He held post-doctoral fellowship positions in different Universities in Canada. He was joined as a tenure track Assistant Professor of Medicine at the University of Vermont. His current position at the University of Central Florida is a Professor and Head, Division of Metabolic and Cardiovascular Sciences, Burnett School of Biomedical Sciences in the College of Medicine at the University of Central Florida, Orlando, Florida. His major area of research is related to stem cells, heart failure, diabetes, inflammation and cardiac regeneration. Additionally, he is exploring how to use the cutting edge technology of 3D printing for pediatric surgeons to perform accurate surgery on the diseased hearts of new born babies. He is continuously serving to review the grants for various NIH, AHA, ministry of Italian health, and Hong Kong study sections. He is an Academic Editor for PLos one, Associate Editor for Canadian Journal of Physiology and Pharmacology as well as he is serving on the Editorial board member for different journals such as American Journal of Physiology: Heart and Circulatory. He is a chair, TPIG committee, American Physiology Society and also currently is a secretary North American section of the International Academy of Cardiovascular Sciences. He is a fellow international academy of cardiovascular sciences. He is a reviewer for different journals. He served as a chair for various scientific sessions throughout the world. He has also organized scientific conferences. He is an author or coauthor for more than 87 peer reviewed papers